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Anabolic steroid and gonadotropin releasing hormone analog combined treatment increased pubertal height gain and adult height in two children who entered puberty with short stature. The patients' height gains ranged from 3 to 5 cm. The authors concluded that "long term use of GnRHa and oral testosterone for treatment-resistant boys with low bone density might have potential for enhancing bone growth in this population." Growth acceleration. A retrospective study evaluating growth rates in girls exposed to GH. The growth rate in 12 girls with GH exposed to the treatment was faster than in 13 girls whose mothers received placebo during the postnatal period. Also, girls with GH exposed families had longer periods of amenorrhoea than did treated controls. The authors conclude that increased GH exposure results in longer growth rates and may lead to premature puberty. Puberty suppression. A double analysis of a large population study involving over 3000 girls concluded that girls with GH treated families had shorter puberty, lower androgen levels in pubertal cycles, and shortened menses and menstruation. The report concluded that "the GH/IGF-I group's reduced puberty was probably due to the suppression of maturation of puberty. It is not possible to establish whether these effects of GH were reversible, especially under natural conditions, for all treated families with normal levels of GH in the premenstrual period." Hereditary changes and gonadal cancer. Another study involving over 6000 girls and boys exposed to GH, compared the incidence of cancer of the breast and ovaries in girls exposed to GH and matched controls. Girls with GH exposed parents were found to have a higher incidence of breast cancer. Girls with GH treated mothers were found to be at increased risk for ovary tumors. The incidence levels of leukemia, lymphoma and squamous cell carcinoma of the breast were greater among girls with GH exposed parents than among controls. The authors conclude that "increased GH exposure may increase the risk of breast diseases among women." Hereditary effects of hormonal influences on thyroid function. A double analysis of a population study involving over 500 children exposed to GH and matched controls. Subjects receiving GH had significantly decreased thyroid function scores and elevated T3 levels in adulthood. The study concluded that, "the reduced thyroid function levels and hyperthyroidism observed in a large number of patients with GH treatment probably represent irreversible changes related to the long term hormonal influences on thyroid functioning. They should be addressed and evaluated in future studies." A prospective population study of over 3200 children exposed to GH and matched controls. These children had a significantly reduced Related Article: